Best open source Python repositories on GitHub

NousResearch/hermes-agent

Python

The agent that grows with you

harry0703/MoneyPrinterTurbo

Python

利用 AI 大模型和自动化工作流，根据主题或关键词一键生成高清短视频。Generate HD short videos from a topic or keyword with an automated AI workflow.

Comfy-Org/ComfyUI

Python

The most powerful and modular diffusion model GUI, api and backend with a graph/nodes interface. The fastest local inference engine in the world.

home-assistant/core

Python

:house_with_garden: Open source home automation that puts local control and privacy first.

vllm-project/vllm

Python

A high-throughput and memory-efficient inference and serving engine for LLMs

bytedance/deer-flow

Python

An open-source long-horizon SuperAgent harness that researches, codes, and creates. With the help of sandboxes, memories, tools, skill, subagents and message gateway, it handles different levels of tasks that could take minutes to hours.

BerriAI/litellm

Python

The fastest, litest AI Gateway. Rust core with Python SDK. Call 100+ LLM APIs in OpenAI (or native) format with cost tracking, guardrails, load balancing, and logging [Bedrock, Azure, OpenAI, Anthropic, OpenAI, VertexAI, vLLM, Nvidia NIM]

docling-project/docling

Python

Get your documents ready for gen AI

vnpy/vnpy

Python

基于Python的开源量化交易平台开发框架

zhayujie/CowAgent

Python

Open-source personal AI assistant & Agent Harness. Plans tasks, runs tools and skills, self-evolves with memory and knowledge. Multi-agent, multi-model, multi-channel. Lightweight, extensible, one-line install.

sickn33/agentic-awesome-skills

Python

AAS Core is the local, agent-first control plane for complete catalog discovery, agent-owned selection, stack validation, and planning, backed by 2,400+ agentic skills. Includes CLI, local MCP, catalog, plugins, and Workbench.

sgl-project/sglang

Python

SGLang is a high-performance serving framework for large language models and multimodal models.

streamlit/streamlit

Python

Streamlit — A faster way to build and share data apps.

deepspeedai/DeepSpeed

Python

DeepSpeed is a deep learning optimization library that makes distributed training and inference easy, efficient, and effective.

SimplifyJobs/Summer2027-Internships

Python

Summer 2027 software engineering, data science, AI, quant, product management, and hardware internship postings. Updated daily by Simplify and Pitt CSC.

searxng/searxng

Python

SearXNG is a free internet metasearch engine which aggregates results from various search services and databases. Users are neither tracked nor profiled.

PDFMathTranslate/PDFMathTranslate

Python

[EMNLP 2025 Demo] PDF scientific paper translation with preserved formats - 基于 AI 完整保留排版的 PDF 文档全文双语翻译，支持 Google/DeepL/Ollama/OpenAI 等服务，提供 CLI/GUI/MCP/Docker/Zotero

rocketride-org/rocketride-server

Python

High-performance AI pipeline engine with a C++ core and 50+ Python-extensible nodes. Build, debug, and scale LLM workflows with 13+ model providers, 8+ vector databases, and agent orchestration, all from your IDE. Includes VS Code extension, TypeScript/Python SDKs, and Docker deployment.

kovidgoyal/calibre

Python

The official source code repository for the calibre ebook manager

ArchiveBox/ArchiveBox

Python

🗃 Open source self-hosted web archiving. Takes URLs/browser history/bookmarks/Pocket/Pinboard/etc., saves HTML, JS, PDFs, media, and more...