Best open source Python repositories on GitHub

NousResearch/hermes-agent

Python

The agent that grows with you

langchain-ai/langchain

Python

The agent engineering platform.

pytorch/pytorch

Python

Tensors and Dynamic neural networks in Python with strong GPU acceleration

langflow-ai/langflow

Python

Langflow is a powerful tool for building and deploying AI-powered agents and workflows.

vllm-project/vllm

Python

A high-throughput and memory-efficient inference and serving engine for LLMs

commaai/openpilot

Python

openpilot is an operating system for robotics. Currently, it upgrades the driver assistance system on 300+ supported cars.

pandas-dev/pandas

Python

Flexible and powerful data analysis / manipulation library for Python, providing labeled data structures similar to R data.frame objects, statistical functions, and much more

BerriAI/litellm

Python

The fastest, litest AI Gateway. Rust core with Python SDK. Call 100+ LLM APIs in OpenAI (or native) format with cost tracking, guardrails, load balancing, and logging [Bedrock, Azure, OpenAI, Anthropic, OpenAI, VertexAI, vLLM, Nvidia NIM]

hesreallyhim/awesome-claude-code

Python

A hand-picked collection of the finest of resources for the most awesome of agents, Claude Code, the undisputed champion of coding companions, from the unstoppable team at Anthropic PBC. A delectable showcase of top tier skills, ambidextrous agents, scintillating status lines, top notch developer tooling, and also we have plugins

numpy/numpy

Python

The fundamental package for scientific computing with Python.

getsentry/sentry

Python

Developer-first error tracking and performance monitoring

SimplifyJobs/Summer2027-Internships

Python

Summer 2027 software engineering, data science, AI, quant, product management, and hardware internship postings. Updated daily by Simplify and Pitt CSC.

sgl-project/sglang

Python

SGLang is a high-performance serving framework for large language models and multimodal models.

PostHog/posthog

Python

:hedgehog: PostHog is the leading platform for building self-driving products. Our developer tools – AI observability, analytics, session replay, flags, experiments, error tracking, logs, and more – capture all the context agents need to diagnose problems, uncover opportunities, and ship fixes. Steer it all from Slack, web, desktop, or the MCP.

tinygrad/tinygrad

Python

You like pytorch? You like micrograd? You love tinygrad! ❤️

onyx-dot-app/onyx

Python

Open Source AI Platform - AI Chat with advanced features that works with every LLM

ocrmypdf/OCRmyPDF

Python

OCRmyPDF adds an OCR text layer to scanned PDF files, allowing them to be searched

tirth8205/code-review-graph

Python

Local-first code intelligence graph for MCP and CLI. Builds a persistent map of your codebase so AI coding tools read only what matters, with benchmarked context reductions on reviews and large-repo workflows.

521xueweihan/GitHub520

Python

:kissing_heart: 让你“爱”上 GitHub，解决访问时图裂、加载慢的问题。（无需安装）

airbytehq/airbyte

Python

Open-source data movement for ELT pipelines and AI agents — from APIs, databases & files to warehouses, lakes, and AI applications. Both self-hosted and Cloud.